MOTS-C is a relatively new peptide of 16 amino acids that promote metabolic balance. It regulates metabolic functions throughout the body. For instance, it turns glucose into usable energy. The DNA in the cell nucleus encodes most peptides.
Research is showing MOTS-C peptide is an exercise mimetic, a 16-amino-acid peptide that is encoded in the mitochondrial genome of cells. According to clinical studies, it improves insulin sensitivity. While the study is still ongoing, control group examinations using diet-induced obese mice have shown improvements in insulin sensitivity. Researchers are still studying to see if the MOTS-c changes plasma markers, which are used to determine the body’s metabolic condition.
Research has shown that it targets body muscles and regulates its metabolism using the folate-purine-AMPK pathway. By doing so, it becomes effective protecting against obesity and insulin resistance that stems from the diet that one is taking or age.
How Mots-C Peptide Regulates Glucose
Clinical studies have shown that MOTS-c promotes the production of endogen AMP analogue AICAR, which in turn, helps in the synthesis of AMPK-activated protein kinase. Before the production of AMPK, its cellular actions inhibit the folate cycle along with de novo purine biosynthesis. The AMPK then induces systemic cellular uptake of glucose and enhances insulin sensitivity. These studies suggest the mitochondria offer active regulation of metabolic homeostasis via this peptide encoded in their genome.
Research confirms that the peptide genome can help reduce insulin resistance. Health experts recommend taking the medication along with a focused, balanced diet to lower the amount of fat taken to manage obesity. Other studies have shown that general weight gain may increase insulin insensitivity, especially on diabetes type 1 patients. Cutting down the fat intake and increased levels of MOTS-c may lower the diet-induced metabolic dysfunction and associated inflammation.
Benefits of MOTS-c include:
• Helps regulate energy
• Protects against obesity
• Helps with weight loss
• Improves exercise capacity
• Improves glucose regulation
• Improves metabolism
• Helps improve overall health and wellness
MOTS-c peptide showed an affinity to reverse age-dependent insulin resistance in various muscles. Insulin is a peptide hormone produced in the pancreas and helps blood sugar enter blood cells. This is so that it can be used as energy. Therefore, MOTS-c reversing age-dependent insulin resistance has the potential to lead to the improvement of our body’s muscle uptake of glucose.
Now, since it is able to assist in the reversal of insulin resistance, it also by default has the ability to aid in the metabolism in fat mass. This is possible because when MOTS-c was introduced to mice it helped in the increase of brown fat function and the reduction of what is known as adipose tissue.
Other things to note about the peptide MOTS-c is that it also showed an ability to prevent adipose dysfunction and inflammation in its subjects as well.
MOTS-c Benefits & Side Effects
MOTS-c peptide does several things for the body when taken. Primarily it aids with the metabolism and mitochondrial energy. However, it has also shown an affinity as a protection against age and diet dependent insulin resistance and subsequent obesity.
No side effects have been noted on the use of this peptide.
Dosage and frequency
Recommended dosage is 5mg in a morning taken on an empty stomach, and before exercise in an ideal world.
Take 5mg every 5th day over a 20 day period and repeat this every 3 months.